The Spanish champions led for much of the match against their top-four rivals last Sunday, but a late equaliser cost Atletico the chance to close the gap to the top two.
Atletico's form has been patchy recently, with just one win from their last four league outings but just one defeat in their last eight.
Guilherme Siqueira will be missing again as he was booked last time out on his return from suspension for a sending-off against Almeria last month, while Mario Mandzukic also misses out after picking up his fifth booking of the season against Valencia.
Saul Niguez is continuing to recover from a blow to the kidneys which left him in hospital last month, but Arda Turan should be available after making his first start since injuring his hamstring in February in last Sunday's clash.
Meanwhile, Espanyol will be hoping to cement their place in the top half of the table as they push for their third win in five matches in the Spanish top flight.
The Catalan side, who currently sit 10th, missed the chance to move as high as eighth last weekend as they slipped to a narrow defeat to Real Sociedad, who are now just two points behind them.
Goalscoring has been a problem for Sergio Gonzalez's side recently, with the team averaging just a goal a game in their last five outings. Top scorer Christian Stuani has not found the back of the net since February.
When the teams met at Vicente Calderon earlier in the season, the home side secured a 2-0 victory.
Form in La Liga: LLWLWL
Form in all competitions: DLWWLL
Possible starting lineup: Casilla, Morena, Alvari, Arvilla, Duarte, Canas, Gonzalez, Lopez, Lucas, Garcia, Stuani
Form in La Liga: WWLWDD
Form in all competitions: WLWLDD
Possible starting lineup: Moya, Godin, Hernandez, Juanfran, Gimenez, Tiago, Koke, Turan, Gabi, Garcia, Torres
Sports Mole says: 0-2