Osasuna have lost just two of their last seven fixtures at home, while Atletico will be looking to go joint top of La Liga with Real Madrid with a win.
Simeone has insisted that it will be a tough test for his side as Osasuna need a win too, and urged his players to go out and play with confidence.
"It will be a difficult game against a rival who will feel comfortable on their own pitch, with an intense pace," Simeone told reporters.
"We have to get on to the pitch with confidence because they will be a strong opponent with great enthusiasm and creativity.
"They also need a win, like us. I think that will make a fun game."
Atletico currently sit in third place in La Liga.