Victory for the capital outfit would move them six points clear of second-place Barcelona with just two games remaining, but Simeone has warned his side to expect a tough test.
"Levante will be very difficult. We struggled in the first game and we imagine another game of this nature," Simeone told reporters at a press conference.
"They'll have great intensity and will be very competitive, as a Levante team always is. We require a lot.
"It's important and logical that after a full season the players don't get off the [game by game] line and it's still maintained today. We haven't won anything. Reality always brings me back to what matters, the League."
Fellow title rivals Real Madrid face Valencia in the late start this evening.