Diego Simeone's team travel to the Bernabeu for the first leg on Wednesday in a repeat of last season's final, which Atletico won 2-1.
"They are totally different competitions. We've done our job today and Wednesday is a nice tie in a competition in which we defend the title against arch-rivals," he told reporters.
"We return to the Bernabeu. It will be a very nice game and we will do the things we do to try to get a positive result. The important thing is that we are all 100%."
Atletico currently top La Liga by three points.