Zinedine Zidane's unwillingness to use Isco in the big matches this season is reportedly pushing the Spaniard towards the Real Madrid exit ahead of the January transfer window.
The 28-year-old has represented Los Blancos on nine occasions this term, but he played just 13 minutes of Champions League football across the club's six group matches, while he did not feature in the recent La Liga clashes with Barcelona, Sevilla and Atletico Madrid.
According to Marca, Madrid boss Zidane is pushing the playmaker towards a move in January, when he will enter the final 18 months of his contract at the Bernabeu.
The Spain international has played over 300 times for Los Blancos since arriving from Malaga in 2013, scoring 51 times and providing 54 assists in the process.
Isco has won two La Liga titles and four Champions League crowns during his time at the club.