A win tonight would see the Gunners close the gap on fourth-placed Liverpool to just one point and Giroud is picked to lead the line ahead of Danny Welbeck, who drops to the bench following the 2-0 win at Southampton on Wednesday night.
Mesut Ozil and Alexis Sanchez continue to provide attacking support for the Frenchman in a 3-4-2-1 formation.
Laurent Koscielny returns to the fold at left-back after missing the trip to the south coast with a calf problem, with Rob Holding on the left of the back three and Shkodran Mustafi continuing at centre.
Hector Bellerin is back in the lineup and is deployed as a right winger, with Nacho Monreal on the left. Francis Coquelin joins up with Granit Xhaka in the middle of the park with Aaron Ramsey dropping to the bench and Kieran Gibbs missing out on the matchday squad.
Alex Oxlade-Chamberlain is also absent due to a calf injury.
Stoke City: Butland; Johnson, Shawcross, Martins Indi, Pieters; Whelan, Cameron, Allen; Arnautovic, Shaqiri; Diouf
Subs: Grant; Muniesa, Berahino, Adam, Walters, Crouch, Ramadan
Arsenal: Cech; Holding, Mustafi, Koscielny; Bellerin, Coquelin, Xhaka, Monreal; Ozil, Sanchez; Giroud
Subs: Ospina, Gabriel, Elneny, Ramsey, Walcott, Iwobi, Welbeck
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