The Spaniard made a bold team selection for last weekend's game against Leicester City and was rewarded with one of the Gunners' best wins of the season, so the likes of Pierre-Emerick Aubameyang, Bukayo Saka, Rob Holding and Hector Bellerin face a task in persuading the manager to bring them back into the fold.
Aubameyang has scored seven times against Burnley in the past - more than he has managed against any other team in the competition - but he netted at the wrong end in the reverse fixture, when his own goal gifted the Clarets all three points.
The skipper may be forced to watch on from the bench again this week if Arteta opts to keep faith with those who produced the win over Leicester last time out.
That would also mean another start for Alexandre Lacazette, who has scored seven away league goals already this season, and Nicolas Pepe, who has netted in four of his last five away league appearances.
Willian will also be hopeful of keeping his place, although his spot is perhaps more under threat, with Saka in particular pushing for a recall.
Arsenal's only major fitness concern surrounds Emile Smith Rowe, who was forced off shortly before half time in the win over Leicester and will be assessed ahead of this game.
Real Madrid loanee Martin Odegaard provides a ready-made replacement if Smith Rowe misses out as expected.
Arsenal possible starting lineup: Leno; Cedric, Luiz, Mari, Tierney; Thomas, Xhaka; Pepe, Odegaard, Willian; Lacazette
Watch the Sports Mole Football Shorts prediction for this game below: