His inclusion is one of eight changes for Arsene Wenger's side following their 2-1 win over Everton at the weekend, as Alex Oxlade-Chamberlain, Olivier Giroud and Petr Cech are the only players to retain their places.
Meanwhile, the home side have made just two changes following their victory over South Yorkshire rivals Rotherham United in the Championship last time out.
Sheffield Wednesday: Wildsmith; Hutchinson, Loovens, Lees, Helan; Joao, Lee, Hunt, Wallace; Pudil, Bannan
Subs: Price, Palmer, Semedo, Nuhiu, McGugan, Bus, Sasso
Arsenal: Cech; Debuchy, Chambers, Mertesacker, Gibbs; Gibbs, Flamini, Kamara, Oxlade-Chamberlain, Iwobi; Campbell, Giroud
Subs: Macey, Paulista, Walcott, Monreal, Bennacer, Bielik, Sheaf
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