Changes could be on the cards for this third match in the busiest month of the year, especially after losing a couple of players to injury at Old Trafford.
Ramsey and Holding were both forced off against United on Wednesday, with the latter suffering what Emery described as a "big" injury that could keep him ruled out for the long term.
The ankle injury sustained by Ramsey is not thought to be as serious, but the Gunners are unlikely to risk the Welsh midfielder during this busy run of fixtures.
Ramsey's absence may coincide with the return of Ozil, who has sat out Arsenal's last four matches with a back complaint.
Ozil enjoys playing against Huddersfield, having scored one and set up two more in a 5-0 home win at the Emirates Stadium last season.
Elsewhere, Granit Xhaka returns from suspension and should take over from Matteo Guendouzi in a like-for-like change in the engine room, while Alexandre Lacazette is in line for a return up front should Emery decide to revert back to a 4-2-3-1 formation to compensate for the loss of Holding.