The Gunners face a Frankfurt side whose 5-1 demolition of Bayern Munich led to the sacking of Niko Kovac, and a similar result in London could see the Spaniard meet the same fate.
Arsenal have failed to win in their last six games across all competitions and the pressure is growing on under-fire coach Unai Emery.
Three draws and two defeats in the Premier League has seen the gap between the Gunners and the top four grow to eight points, with Arsenal slipping into eighth in the table.
Arsenal have not even found respite in the cup competitions, despite having started so promisingly in both the Europa League and the EFL Cup, drawing 1-1 with Vitoria de Guimares in the former and going out on penalties after a bonkers 5-5 draw at Anfield in the latter against a weakened Liverpool side.
However, a win against their German opponents would be enough to secure their status as group winners, and just a point is needed to guarantee their place in the knockout stages.
Frankfurt have struggled of late, losing each of their last three across all competitions since their emphatic thumping of reigning Bundesliga champions Bayern.
However, they are still very much in contention to qualify and are level on points with Standard Liege in the group, but are behind only on goals scored.
Any unlikely points in London would go a long way towards their progression to the knockout stages after a mixed season as they struggle to adapt to life without either Luka Jovic or Sebastian Haller.
Arsenal form: DLDDLD
Eintracht Frankfurt form: LWWLLL
Arsenal are without on-loan midfielder Dani Ceballos due to a thigh problem, and he has been ruled out of the game.
However, Emery is likely to make as many changes as he can, as is his policy with the early rounds of the cup competitions.
Aside from the pair, they have a fully-fit squad to choose from.
Arsenal possible starting lineup:
Martinez; Chambers, Mustafi, Mavropanos, Tierney; Torreira, Willock; Maitland-Niles, Smith Rowe, Nelson; Martinelli
Eintracht Frankfurt possible starting lineup:
Ronnow; Abraham, Hasebe, Hinteregger; Da Costa, Fernandes, Rode, Kostic; Sow; Paciencia, Silva
We say: Arsenal 2-2 Eintracht Frankfurt
Arsenal seem to be in a rut at the moment and Emery appears to be crumbling under the pressure. He can't seem to help himself but invite pressure after taking the lead and yet another disappointing home performance could spell the end for the Spaniard.