Arsenal are heavy favourites to progress as they host a team who were in the fourth tier of Swedish football when Potter took over in 2011.
"You need one of the biggest football miracles to go through, so we have nothing to lose," the 42-year-old told Sky Sports News.
"The only thing you have is the regret of not giving it everything. It is a wonderful opportunity for the players and myself to have this experience.
"We start 3-0 down and are away, we are coming to the Emirates - it is as tough a place as anywhere in world football.
"We will be proud of what we have done, no matter what the result is we will leave with our heads held high."
Arsenal have lost just one of their last 27 matches at the Emirates, winning 22 and drawing four since a 5-1 defeat to Bayern Munich last March.