Mikel Arteta's men advanced to this stage courtesy of a dramatic comeback victory over Benfica, with a 3-2 triumph in the second leg seeing the Gunners progress 4-3 on aggregate thanks to late goals from Kieran Tierney and Pierre-Emerick Aubameyang.
However, Arsenal's preparations for this game did not go smoothly as they threw away two points at Burnley in catastrophic fashion, with Granit Xhaka's farcical error seeing the Clarets salvage a 1-1 draw at Turf Moor on Saturday.
Here, Sports Mole rounds up all of Arsenal's injury and suspension news ahead of the first leg.
Status: Major doubt
Type of injury: Hip
Possible return date: March 11 (vs. Olympiacos)
Emile Smith Rowe was forced off in the win at Leicester City with discomfort in his hip and did not make the trip to Burnley. However, Arsenal have revealed that the playmaker is not nursing anything "significant", so he could very well return this week.
ARSENAL'S SUSPENSION LIST
Arsenal have no players suspended for the first leg or at risk of suspension for the second leg.