The Gunners currently top Group B following wins over Montpellier and Schalke, while Schalke sit second after picking up four points from their first two matches.
Arsene Wenger's side have not lost a home fixture to non-English opposition since losing to Inter Milan in 2003. Schalke, meanwhile, have only won one of their last eight European games against English opposition.
Arsenal: Mannone; Jenkinson, Mertesacker, Vermaelen, Santos; Arteta, Ramsey; Gervinho, Cazorla, Podolski; Giroud
Schalke: Unnerstall; Uchida, Howedes, Matip, Fuchs; Neustadter, Hoger, Farfan, Holtby, Afellay; Huntelaar
Sports Mole says: 2-2