The home side will be hoping to avoid a repeat of the fate that they suffered in the reverse meeting, where they were outclassed in a 4-0 demolition back in November.
A 3-0 win over FC Twente on Saturday moved PSV to within four points of Ajax, whose game against Utrecht, that was scheduled for the next day, got called off.
Roger Schmidt's men have maintained their fantastic home record - the best in the division - as they had too much quality for their most recent visitors.
The Rood-witten have one less competition to focus on due to the fact that they have been knocked out of the KNVB-Beker by Ajax, who came out on top in a 2-1 victory.
However, the league, as well as the Europa League, are still possible sources of silverware for PSV as they go in search of a first major trophy since 2018.
A win for Saturday's visitors would temporarily take them within a point of Ajax, who will be in action against Heracles a few hours later.
ADO Den Haag were held to a second consecutive home draw in eight days, as they played out a 1-1 stalemate versus Sparta Rotterdam two Sundays ago.
On Saturday, they were to be involved in a crucial game against Willem II, who are only a point and a place above them in the Eredivisie table, but the game was eventually postponed.
De Residentieclub can take solace from the fact that they are only four points away from safety, and they also have a game in hand on 15th-placed Waalwijk, who they will be going up against later in the month.
ADO Den Haag Eredivisie form: WLLDLD
ADO Den Haag form (all competitions): LLLDLD
PSV Eindhoven Eredivisie form: LWWWLW
PSV Eindhoven form (all competitions): WWWLWL
With one eye on the Europa League tie at Olympiacos five days later, Roger Schmidt could be making some alterations to his team for this one ahead of their trip to Greece.
Den Haag's impressive draw against Sparta came at a price as they lost John Goossens to injury midway through the second half.
The 32-year-old Dutch midfielder has been the main creative hub for his side this season, setting up the most goals, and he will be a big miss should he be deemed unfit to play.
Hoping to impress in his absence will be Shaquille Pinas, who is going through a dry spell at the moment in stark contrast to his explosive start to the season.
ADO Den Haag possible starting lineup:
Koopmans; Familio-Castillo, Kemper, Del Fabro, Van Ewijk; Pinas, Vejinovic, Pinas; Bourard, Kramer, Besuijen
PSV Eindhoven possible starting lineup:
Mvogo; Max, Boscagli, Teze, Dumfries; Rosario, Sangare, Thomas; Junior, Vertessen, Zahavi
We say: ADO Den Haag 0-2 PSV Eindhoven
PSV have an opportunity to move as close to Ajax as they have been in a long while, and we do not expect them to pass up that chance against a relegation-threatened Den Haag side.