In a meeting between two sides bidding to be crowned NBA champions, it was the Spurs who were dominant throughout at both ends of the court as Tony Parker scored 22 points to help his side to a franchise-record 18th straight victory.
After closing the first half on a 22-9 run, the Heat never trailed again as they cruised to success in front of their own supporters at the AmericanAirlines Arena.
The Charlotte Bobcats fought back from an 11-point deficit in the fourth quarter to beat the Washington Wizards 100-94.
Kemba Walker finished with 21 points and 10 assists as the Bobcats prevented the Wizards from securing their spot in the playoffs.
Paul Millsap recorded 28 points and 17 rebounds to help the Hawks continue their bid to finish in the final playoff spot in the Eastern Conference.
The Pistons went on a 12-0 run to take the lead in the final quarter, before a late three-point effort from Josh Smith secured the victory.
Joakim Noah added 19 points and 11 rebounds for the Bulls, who took full control of the contest with 13 unanswered points early in the fourth quarter.
The Kings were just a point ahead of the Pelicans at one stage in the fourth quarter, but 35 points and 14 rebounds from Cousins proved to be key as they ended a three-game losing streak.
The Grizzlies, who are still in the hunt for seventh spot in the Western Conference, were put under pressure when Timofey Mozgov dunked to make it 93-92 late on, but they failed to find the final score which would have handed them the win.
A 92-83 victory for the Knicks means that they remain strong contenders for the final playoff spot in the Eastern Conference.