Bill Belichick's side face off against the Broncos at Gillette Stadium in the battle for the top seed in the AFC, and the 24-year-old feels that his side will have to be aggressive to knock Peyton Manning and his offense off rhythm.
Hightower told reporters: "Definitely want this to be a physical game on our part. They have a lot of big receivers, a lot of quick guys.
"The one thing we are going to have to do that I think we are pretty good at is being aggressive. Whether it is jamming or they have a lot of crossers, so just being aggressive and coming down on that.
"Peyton [Manning] is going to get those guys the ball no matter how or when or whether they are double-covered or whatever. We are just going to have to do a real good job on the line of scrimmage and just be aggressive with these guys."
The Patriots have a 6-2 record this season going into the matchup against the Broncos.