The wide receivers have both been limited in practice this week, as Blackmon is dealing with groin and hamstring injuries, while Shorts picked up a shoulder knock during last week's loss to the Denver Broncos.
Head coach Gus Bradley told ESPN: "We feel better about Justin Blackmon. He got quite a few reps yesterday and we wanted to make sure that he would be available on Sunday."
Shorts added: "I'm getting better each day and we'll go from there. It's something I'll fight through."
Shorts leads the team with 411 receiving yards so far this season, while Blackmon, who was suspended for the first four games, has 326 yards.