Second-placed Sarries are two points off leaders Harlequins, while the Tigers are one point behind their opponents this weekend.
Meanwhile, Toby Flood and Manu Tuilaigi miss out because of England duty.
Leicester: Murphy, Hamilton, Smith, Bowden, Thompstone, Ford, Harrison, Ayerza, Hawkins, Mulipola, Slater, Kitchener, Croft, Salvi, Crane
Replacements: Chuter, Brookes, Balmain, Deacon, Thorpe, Young, Cornwell, Tait
Saracens: Wyles, Short, Tomkins, Powell, Strettle, Hodgson, Wigglesworth, Gill, Brits, Stevens, Borthwick, Hargreaves, Wray, Fraser, Joubert
Replacements: Smit, Auterac, Du Plessis, Kruis, Melck, De Kock, Mordt, Taylor
Sports Mole says: Saracens to edge out Leicester