While the Hammers are level on 13 points with 18th-placed Fulham and out of the relegation zone only on goal difference, their visitors are rooted to the foot of the table having picked up only eight points from 15 matches.
Guy Poyet's team will be without goalkeeper Keiren Westwood and defender Carlos Cuellar, while West Ham will have winger Stewart Downing unavailable because of an ankle injury he suffered against Liverpool.
Kevin Nolan is suspended for receiving a red card against the Reds, while Ricardo Vaz Te (shoulder), Winston Reid (ankle) and Mladen Petric (calf) will also sit out Saturday's encounter for the hosts.
Striker Andy Carroll remains on the sidelines despite having started light training in an effort to recover from a foot injury.
However, 20-year-old Ravel Morrison will be back from suspension for the Hammers and is likely to slot back into the starting lineup.
West Ham: DLLWLL
Possible starting lineups
West Ham: Jaaskelainen; Demel, Collins, Tomkins, McCartney; Noble, Diame; Cole, Morrison, Jarvis; Maiga
Sunderland: Mannone; Celustka, O'Shea, Brown, Bardsley; Larsson, Ki, Colback, Johnson; Altidore, Fletcher
Sports Mole says: 1-0