Gylfi Sigurdsson starts for Tottenham Hotspur in the North London derby against Arsenal, while Lewis Holtby drops to the bench.
Sigurdsson will be joined by Aaron Lennon and in-form Gareth Bale, who will support lone striker Emmanuel Adebayor.
Moussa Dembele and Scott Parker make up the midfield for Andre Villas-Boas's side, with Michael Dawson and Jan Vertonghen partnering each other in the centre of defence.
Meanwhile, Arsene Wenger has Santi Cazorla, Theo Walcott and Jack Wilshere in behind Olivier Giroud, who leads the line at White Hart Lane.
Aaron Ramsey and Mikel Arteta start in central midfield, while Carl Jenkinson comes in at right full-back.
Tottenham: Lloris, Walker, Dawson, Vertonghen, Assou-Ekotto, Dembele, Parker, Sigurdsson, Lennon, Bale, Adebayor
Arsenal: Szczesny, Jenkinson, Mertesacker, Vermaelen, Monreal, Ramsey, Arteta, Wilshere, Cazorla, Walcott, Giroud
