Pochettino made sweeping changes for the club's Europa League clash with Partizan, but the likes of Christian Eriksen, Erik Lamela and Emmanuel Adebayor are all expected to find themselves back in the team.
West Brom have endured a poor start under the leadership of Alan Irvine, and the former Everton academy coach is under pressure to deliver his first win at The Hawthorns.
Fellow newcomer Joleon Lescott is nearing a return to full fitness and could be included in the 18-man squad.
Tottenham Hotspur: WWLDD
West Bromwich Albion: DDDLL
Possible starting lineups
Tottenham Hotspur: Lloris; Dier, Kaboul, Chiriches, Rose; Dembele, Capoue; Lamela, Eriksen, Chadli; Adebayor
West Bromwich Albion: Foster; Wisdom, Gamboa, Olsson, Dawson; Dorrans, Gardner, Morrison, Brunt; Berahino, Samaras
Sports Mole says: 2-0