Ignacio Monreal is picked in defence, with Jordi Alba missing out.
Syarhey Vyeramko continues in goal for the visitors while the experienced Timofei Kalackev also starts.
A win tonight will leave La Roja needing just a point from their final game to qualify for the World Cup.
The game does go ahead despite an electrical generator exploding at the Iberostar yesterday.
Spain: Valdes, Arbeloa, Ramos, Pique, Monreal, Xavi, Busquets, Pedro, Fabregas, Michu, Silva
Belarus: Veremko; Martynovich, Verkhovtsov, Bordachev, Filipenko; Dragun, Zhavnerchik, Putilo, Balanovich; Tigorev, Kalachev