Wednesday followed up an impressive opening-day win at Brighton & Hove Albion with a goalless draw at Derby County on Saturday, while Millwall are one of just two teams with a 100% record, backing up victory over Leeds United with three points at Fulham.
Both games between these two last season finished as score-draws, while Wednesday are unbeaten in five games against the Lions.
Millwall's last win at Hillsborough was almost nine years ago.
Possible starting lineups
Wednesday: Westwood; Palmer, Loovens, Lees, Mattock; Maguire, Coke, Hutchinson, Maghoma; May, Nuhiu
Millwall: Forde; Edwards, Dunne, Beevers, Briggs; Abdou, Williams; Martin, McDonald, Woolford; Fuller
Sports Mole says: 1-1