The away side were then reduced to nine men in the second period with Fran Gonzalez giving away a penalty, allowing Negredo to score from the spot.
Meanwhile, there was time for one last piece of drama as Manu del Moral ghosted into the box to make it four for the home side in the final stages.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
SEVILLA: Lopez; Navarro, Spahic, Fazio, Cicinho; Reyes, Rakitic, Kondogbia, Medel, Navas; Negredo
ZARAGOZA: Franco; Paredes, Lanzaro, Sapunaru, Gonzalez; Fernandez, Wilchez, Zuculini, Mari; Javi, Victor