Real Madrid can move seven points clear of bitter rivals Barcelona with a win at the Santiago Bernabeu on Sunday evening.
Carlo Ancelotti's side are currently on an 18-match unbeaten run in La Liga, and they could put a huge dent in Barcelona's title ambitions with three points against the Catalan giants.
Madrid will welcome back defender Sergio Ramos, who sat out last week's win over Malaga due to suspension.
Successive away defeats to Real Sociedad and Real Valladolid has seen Barcelona fall down to third in the league standings.
Coach Gerardo Martino is expected to include Gerard Pique and Neymar after both dropped out of the starting lineup against Osasuna last weekend.
Recent form
Real Madrid: WDWWW
Barcelona: LWLWW
Possible starting lineups
Real Madrid: Diego Lopez; Pepe, Marcelo, Sergio Ramos, Varane; Xabi Alonso, Modric, Isco; Bale, Cristiano Ronaldo, Benzema
Barcelona: Victor Valdes; Dani Alves, Jordi Alba, Pique, Mascherano; Iniesta, Xavi, Busquets; Messi, Alexis Sanchez, Neymar
Sports Mole says: 2-1
No Data Analysis info
