However, it was a case of too little too late with Jose Mourinho's side advancing to the semi-finals courtesy of a 3-1 aggregate score.
There was to be late drama, however, with Angel di Maria receiving a red card as Madrid ended the match with nine men.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
VALENCIA: Guaita; Costa, Rami, Pereira, Cissokho; Ruiz, Guardado, Costa, Viera; Valdez, Jonas
REAL MADRID: Casillas; Arbeloa, Varane, Albiol, Coentrao; Khedira, Alonso, Ozil; Ronaldo, Benzema, Di Maria