Royals boss Brian McDermott has strengthened his squad over the summer in a bid to establish his side in the top flight.
Russian striker Pavel Pogrebnyak, who scored six goals in a loan spell at Fulham last season, is the marquee arrival and he is expected to start against the Potters.
He will compete with Matthew Etherington and Jermaine Pennant for a spot on the Stoke flanks, but Pulis may opt to stay loyal to the pair that provided top-scorer Peter Crouch with a large proportion of his 14 goals last season.
Reading: Federici; Gunter, Marriapa, Gorkss, Harte; Kebe, Guthrie, Leigertwood, McAnuff; Le Fondre, Pogrebnyak
Stoke City: Begovic; Huth, Shawcross, Upson, Wilson; Pennant, Whitehead, Whelan, Etherington; Walters, Crouch
Sports Mole says: 2-1