The Royals have beaten Mick McCarthy's men in their last six meetings, but the former Wolverhampton Wanderers manager has been active during the transfer window, bolstering his squad with 10 new players.
Among the new faces in his squad is former Reading midfielder Jay Tabb, who left Berkshire in May after a four-year stay.
Reading: Federici; Gunter, Pearce, Mariappa, Bridge; Karacan, Guthrie, Robson-Kanu, Drenthe; Le Fondre, Pogrebnyak
Ipswich: Loach; Hewitt, Berra, Veseli, Cresswell; Anderson, Skuse, Tabb, Edwards; Murphy, McGoldrick
Sports Mole says: 2-1