Tony Mowbray's side are also yet to earn a victory at the Riverside Stadium this season, with their only success coming away at Charlton Athletic in the second week of Championship action.
Huddersfield travel to the North-East unbeaten in their last four and also have the league's top scorer fit and firing in James Vaughan.
Possible starting lineups
Boro: Steele, Friend, Richardson, Gibson, Woodgate, Smallwood, Leadbitter, Whitehead, Adomah, Jutkiewicz, Kamara
Huddersfield: 1 Smithies, Clarke, Lynch, Gerrard, Norwood, Scannell, Clayton, Hammill, Richards, Holmes, Vaughan
Sports Mole says: 2-1