United boss David Moyes saw his former club leave Old Trafford with all three points thanks to a late goal from Brian Oviedo.
United will overtake the visitors in the table if they secure victory.
Moyes will have to make changes to his side, with Wayne Rooney suspended after picking up his fifth booking of the season against Everton. With Robin van Persie still ruled out through injury, Javier Hernandez could be handed a start.
Man Utd: WWWDDL
Possible starting lineups
Man Utd: De Gea; Rafael, Vidic, Smalling, Evra; Valencia, Fellaini, Giggs, Kagawa; Welbeck, Hernandez
Newcastle: Krul; Debuchy, Williamson, Coloccini, Santon; Sissoko, Tiote, Cabaye, Gouffran; Shola Ameobi, Remy
Sports Mole says: 2-1