The home side currently sit third in Group B on 12 points, one point behind second-placed Bulgaria with two matches remaining. They have won three, drawn three and lost two of their eight matches thus far, but they head into the fixtures on the back of successive wins over Malta and Armenia.
Italy, meanwhile, have already secured their spot in Brazil having won six of their eight Group B matches, remaining unbeaten in the process and amassing 20 points.
The Azzurri also enter the contest on the back of two successive wins over Czech Republic and Bulgaria and will take confidence from the last time they faced Denmark – a 3-1 win in the corresponding match in October 2012.
In-form Fiorentina striker Giuseppe Rossi has returned to the Italy squad after a two-year absence, while Roma defender Federico Balzaretti has also been included for the first time since November 2012.
Mario Balotelli, Alessio Cerci, Lorenzo Insigne and Pablo Osvaldo have also been selected, while Juventus goalkeeper Gianluigi Buffon will pass Fabio Cannavaro's all-time appearance record for Italy should he earn his 137th cap.
Possible starting lineups
Denmark: Andersen; Jacobsen, Agger, Kjaer, Boilesen; Kvist, Eriksen, Andreasen, Delaney; Bendtner, Fischer
Italy: Buffon; Chiellini, Bonucci, Balzaretti; Abate, De Rossi, Montolivo, Pirlo, Candreva; Balotelli, Rossi
Sports Mole says: 1-1