It has been an excellent start to life as head coach for Luis Enrique, but his side will face their toughest challenge of the campaign so far against last season's fourth-placed side.
Andres Iniesta has been back in training this week, but it remains unclear whether he will be risked ahead of the start of Barcelona's Champions League campaign.
Bilbao are currently three points behind the leaders following one win and one loss from their opening two games, and Ernesto Valverde is likely to name the same team which beat Levante 3-0 before the international break.
Possible starting lineups
Barcelona: Bravo; Alves, Pique, Vermaelen, Alba; Busquets, Rakitic, Rafinha; Pedro, Messi, Munir
Bilbao: Iraizoz, Laporte, Balenziaga, San Jose, De Marcos, Iturraspe, Mikel Rico, Benat, Gomez, Muniain, Aduriz
Sports Mole says: 3-1