Millions are expected to tune in around the world as the Irishman takes on undefeated Mayweather in a boxing ring at the T-Mobile Arena.
McGregor is full of confidence in the build-up to the showdown, insisting that his 8oz gloves - approved by the Nevada State Athletic Commission last week following a U-turn - will give him a helping hand.
"Respect for me is earned through battle," he told Sky Sports News. "If he stands in there and speaks his word of what he's been saying, if he can get in there and implement these and come forward and give the fight he's been talking about, he will have my respect.
"I wouldn't be surprised if I go out there and flatten him in the first exchange, I don't see him lasting two rounds in these 8oz gloves."