The 27-year-old has prepared for the Slam in New York by winning two tournaments this summer on the hard courts.
With that in mind, the North Carolina-born player has admitted that he is feeling confident ahead of the next fortnight.
"I feel pretty good about myself and about my game right now. I have had a pretty similar summer to what I had last year, and I played very well last year," he told reporters. "This tournament feels exactly the same because I came off winning Winston‑Salem and I did that again this year.
"I'm playing well. I believe I can beat anyone, but I also know anybody can beat anybody out here. I'm not looking past anyone. I'm not good enough to do that."
Isner will begin his campaign at Flushing Meadows against Xavier Malisse tomorrow afternoon.