Jim Hamilton, Geoff Cross, Kelly Brown, Rory Lawson, Graeme Morrison and Nick De Luca are the players who make way in their final Pool B match.
England coach Martin Johnson will name his team on Thursday, but Delon Armitage is expected to replace Mark Cueto on the wing, while Matt Stevens is likely to feature ahead of Alex Corbisiero at loose-head prop.
Courtney Lawes could also start after serving a two-match ban.
Scotland team to play England:
Paterson; Evans, Ansbro, Lamont, Danielli; Jackson, Blair; Jacobsen, Ford, Murray, Gray, Kellock (capt), Strokosch, Barclay, Vernon
Replacements: Lawson, Dickinson, Hines, Rennie, Cusiter, Parks, De Luca