There are four changes in personnel and two positional switches to the side that defeated Scotland 13-6 in the Calcutta Cup a fortnight earlier.
Manu Tuilagi returns at outside centre after winning his battle with a minor groin strain that forced him to miss the trip to Murrayfield.
Henry Slade is also present after two months out with an ankle injury but the Exeter Chiefs playmaker must settle for a place on the bench, which once again sees a six-two split between forwards and backs.
The two-way duel for scrum-half duties has been won by Ben Youngs, who ousts Willi Heinz.
Vunipola has returned home to Tonga for family reasons, creating a vacancy in the front row, but Tuilagi's comeback compensates for the loss of his gainline-busting power.
England must defeat Ireland to remain in Six Nations title contention, while Andy Farrell's men are chasing the Grand Slam.
"Ireland are a very good team, extremely well-coached. They are a team we respect a lot," Jones said.
"They will bring their usual physicality and under Andy Farrell they've opened up their game a little bit.
"We've got to make sure we match their physicality and their emotion on the weekend."