Ireland coach Declan Kidney will hand Ulster winger Craig Gilroy his first Six Nations start in their opener against Wales on Saturday.
Gilroy, who is regarded as one of the best young talents in the country, made his debut for Ireland in November's win over Argentina.
Ireland, who lost to Wales last time out, will attempt to open their campaign with victory against a side that has lost their last seven Test matches.
Ireland: Kearney; Gilroy, O'Driscoll, D'Arcy, Zebo; Sexton, Murray; Healy, Best, Ross; McCarthy, Ryan; O'Mahony, O'Brien, Heaslip
Replacements: Cronin, Kilcoyne, Fitzpatrick, Henry, O'Callaghan, Reddan, O'Gara, Earls