There have been doubts cast over Jackson's inclusion following his display in last year's Heineken Cup Final, but O'Driscoll believes that the 21-year-old will perform on Sunday.
"I heard Paddy talking about the learning curve from the Heineken Cup final," Sky Sports News quotes O'Driscoll as saying. "In fact, I think some of the stuff written about him in that game was very harsh. He really didn't have that off a game.
"There were a couple of skewed kicks, but that was the extent of it. He did the fundamental things like tackling well. He passes the ball nicely and takes it to the line.
"That was eight months ago and you've seen his performances throughout the year. It certainly hasn't affected him in any way, shape or form and he deserves his opportunity."
Ireland were defeated 6-12 by England in their last Six Nations outing on February 10.