Billy Burns and James Lowe have been ruled out of Ireland's Autumn Nations Cup third-place play-off with Scotland through injury.
Fly-half Burns has not recovered from the groin issue which cut short his try-scoring full international debut against Georgia on Sunday.
New Zealand-born winger Lowe missed the 23-10 victory over the Lelos and will be absent again this weekend, also due to a groin problem.
Head coach Andy Farrell is seeking a positive end to 2020 following a series of inconsistent performances during the first year of his tenure.
Flanker Will Connors will continue to be monitored after being forced off for a head injury assessment last weekend.