Francois Trinh-Duc will miss France's November Tests after breaking his leg in a Top 14 match between his side Montpellier and Oyonnax.
The fly-half, who will miss the games against Fiji, Australia and Argentina, will undergo an operation later on Saturday.
Montpellier physiotherapist Bruno Boussagol said after the game: "He will be operated on this evening. He will be off games for around three months."
Trinh-Duc, 27, who was not selected for the unsuccessful tour of Australia, suffered the injury when he collided with Argentinian Benjamin Urdipilleta.
