Stand-in Wales boss Rob Howley has also made two alterations to his side from the 33-7 win over Italy last weekend, with Rob Evans and Tomas Francis both being handed starts for the Principality Stadium clash after impressing from the bench in Rome.
The Red Dragons boast plenty of experience in flankers Sam Warburton and Justin Tipuric, who have 70 and 47 caps respectively, and both George North and Dan Biggar have been passed fit in a further boost for the hosts.
Wales team: Halfpenny; North, J Davies, S Williams, L Williams; Biggar, Webb; Evans, Owens, Francis, Ball, Wyn Jones, Warburton, Tipuric, Moriarity
Replacements: Baldwin, N Smith, Lee, Hill, Faletau,G Davies, S Davies, Roberts
England team: Brown; Nowell, Joseph, Farrell, Daly; Ford, Youngs; Marler, Hartley, Cole, Launchbury, Lawes, Itoje, Clifford, Hughes.
Replacements: George, Mullan, Sinckler, Wood, Haskell, Care, Te'o, May