The hosts go into the contest on the back of a convincing 54-12 win over Fiji, but the Aussies will be looking to restore some pride following their 33-6 hammering by France.
The last time that the two teams met was in November 2010 when England ran out 35-18 winners at Twickenham.
England: Goode, Ashton, Tuilagi, Barritt, Sharples, Flood, Care, Marler, T Youngs; Cole, Palmer, Parling, Johnson, Robshaw, Waldrom
Replacements: Paice, Wilson, Vunipola, Launchbury, Wood, B Youngs, Farrell, Brown
Australia: Barnes, Ioane, Ashley-Cooper, Tapuai, Cummins, Beale, Phipps; Palu, Hooper, Dennis, Sharpe, Timani, Alexander, Polota Nau, Robinson
Replacements: Moore, Slipper, Kepu, Samo, Gill, Sheehan, Harris, Mitchell
Sports Mole: England to overcome an improved Australia