Stuart Lancaster's side were defeated 20-14 by the Wallabies at the weekend, but Care is confident ahead of the "hugely exciting task".
"I think the great thing about these internationals is there is such a massive opportunity to play against the best team again next week," Care told Sky Sports News.
"Playing against South Africa at Twickenham again is a hugely exciting task for us. We'll work on a few things Monday and Tuesday I'm sure, review the game, but look forward to what's going to be a massive test and I'm sure you can expect a bit of a backlash from the boys come Saturday."
England defeated Fiji in their first autumn international.