Holders Wigan Warriors booked their place in the fifth round of the Challenge Cup with an emphatic 98-4 win over the North West Crusaders at the DW Stadium.
Sam Tomkins scored six tries on Saturday as Shaun Wane's side eased into the next round.
Meanwhile, Leeds Rhinos progressed on Friday night with a 38-18 home victory over Wakefield Wildcats.
Anthony Bowman, Paul White and Steve Tyrer all bagged two tries each to give Halifax a comprehensive 84-28 triumph at South Wales Scorpions.
However, Castleford Tigers were victims of a giant killing as they went down 23-16 at Featherstone Rovers, while St Helens edged out Windes Vikings 40-38 at the Stobart Stadium Halton.
There was also a big win this weekend for Bradford Bulls, who recorded a 72-6 triumph over Doncaster.
Elsewhere, London Broncos hammered Dewsbury Rams 72-4 at the Twickenham Stoop, while Huddersfield Giants saw off Hull FC 42-16 at the KC Stadium.
Challenge Cup fourth round results:
Leeds Rhinos 38-18 Wakefield Wildcats
South Wales Scorpions 28-84 Halifax RLFC
Swinton Lions 70-10 Gateshead Thunder
Featherstone Rovers 23-16 Castleford Tigers
Windes Vikings 38-40 St Helens
Hunslet Hawks 18-21 Batley Bulldogs
Oldham RLFC 26-14 Barrow Raiders
Leigh Centurions 68-18 Rochdale Hornets
Keighley Cougars 18-44 Warrington Wolves
York City Nights 12-50 Sheffield Eagles
Bradford Bulls 72-6 Doncaster RLFC
Hull KR 18-20 Catalan Dragons
Wigan Warriors 98-4 North West Crusaders
Hull FC 16-42 Huddersfield Giants
Whitehaven RLFC 18-58 Salford City Reds
London Broncos 72-4 Dewsbury Rams
