The Championship new boys can build on their strong start to the 2013-14 season following their opening day victory at The Den against Millwall.
The Glovers then followed up their triumph with another 1-0 win in the League Cup, booting Southend United out of the competition.
At the other end of the pitch, Birmingham have had a mixed start by kicking off the season with a 1-0 defeat to Watford in the Championship, but they managed to lift spirits by securing a 3-2 victory over Plymouth Argyle in the League Cup.
The two sides have never played against each other in a competitive league encounter.
Yeovil Town: WW
Birmingham City: LW
Possible starting lineups
Yeovil Town: Stech; Ayling, Webster, Seaborne, Tate; Foley, Edwards, Upson, Dawson; Ngoo, Hayter
Birmingham City: Randolph; Bartley, Burn, Robinson; Eardley, Adeyemi, Elliott, Shinnie, Ferguson; Novak, Green
Sports Mole says: 1-2