The home side are currently one point above Emmen in the relegation playoff position, while the away side have an extremely small chance of finishing in a playoff position for the UEFA Conference League.
Willem II come into the final fixture of the season after a very important 4-1 win away to bottom-of-the-table ADO Den Haag, which relegated the home side while increasing the chances of survival for the Tricolores.
Den Haag managed to get a goal back in the second half but Che Nunnely ended any concerns of a comeback with a fourth for Willem.
That victory means they come into the last game knowing it is in their hands to avoid relegation from the top flight for the first time since the 2012-13 season.
If Zeljko Petrovic's side fail to win the game, they will be relying on in-form Emmen not to win away to already-relegated VVV-Venlo.
Fortuna Sittard will be aiming to finish the season strongly with a win to secure their current position of 10th in the league, which will be their highest top-flight finish since the 1998-99 campaign.
However, they will be very disappointed after failing to win their last match against Vitesse on Thursday, which has more than likely ended their chances of finishing in the playoff positions.
The manner of the 3-3 draw will certainly hurt Sjors Ultee's side after conceding in the last minute of the match, particularly as midfielder Ben Rienstra opened the scoring in the first minute before Vitesse pulled two back.
This draw means that Fortuna would have to not only win their final match to finish eighth but also need playoff rivals Sparta Rotterdam and Heracles to lose their game, as well as turning around a seven-goal goal difference swing on the former.
However, they may struggle to even win their match as the home team are unbeaten against Fortuna in their last seven meetings at the Koning Willem II Stadion.
Ultee is expected to make no changes to the side that drew 3-3 to Vitesse on Thursday.
Willem II possible starting lineup:
Muric; Owusu, Van Beek, Holmen, Kohn; Nunnely, Saddiki, Llonch, Ndayishimiye; Wriedt, Pavlidis
Fortuna Sittard possible starting lineup:
Osch; Cox, Janssen, Angha, Rota; Rienstra, Tekie; Semedo, Seuntjens, Flemming; Polter
We say: Willem II 2-2 Fortuna Sittard
There is bound to be goals on Sunday with the fixture having over two goals scored in six of the last seven meetings between the sides, with the hosts scoring at least two goals in five of their last six matches against Fortuna Sittard.
Willem II will be desperate for a win to avoid the relegation playoff but their opponents will also want to finish the game strongly, shaping up for an entertaining affair.