The Wanderers went down 2-0 to Melbourne City in their last game and will be out for an upturn in fortune.
Carl Robinson's team have started the season in reasonable touch and sit in fifth spot in the table.
However, worryingly their past two matches have both ended in defeat, to Melbourne City and Adelaide United.
If Western Sydney are to mount a serious title challenge this campaign then they need to get back to winning ways.
Western United are also eyeing a higher position on the ladder after beating Melbourne Victory 4-3 in a pulsating Melbourne derby.
In one of the most thrilling games of the season United displayed great resolve and determination to take all three points right at the death.
Mark Rudan's men have won three and drawn two of their seven fixtures to date.
They head into this game in impressive goalscoring touch, with eight goals from their past two matches, and veteran striker Besart Berisha in a lethal mood.
A win in this fixture would help jump them above the Wanderers in the table.
Historically Western United have never beaten the NSW outfit, with two victories and draw from their three encounters.
They last met in August when the Victorian club sprung a stunning 5-3 win.
Right-back Josh Risdon is still injured and unavailable for Western United.
Dylan Pierias will continue to deputise in his stead at full-back.
Western United possible starting lineup:
Margush; McGowan; Aquilina, Gordon, Georgievski; Dorrans, Baccus, Russell, Muller; Ibini-Isei, Cox
Western Sydney Wanderers possible starting lineup:
Kurto; Calver, Durante, Vujica, Uskok; Sanchez, Lustica, Imai; Pain, Diamanti, Berisha
We say: Western United 2-2 Western Sydney Wanderers
Wester United cannot stop scoring goals at the moment, while Western Sydney are finding it hard to collect wins. A draw between these two interstate rivals is the most likely outcome.