Meanwhile, Harrogate have quickly settled into life in the fourth tier, starting their first ever League Two campaign with a 4-0 victory at Southend United.
When West Brom were provided with a home encounter against the Foxes in their first encounter back in the top flight, Slaven Bilic would have been optimistic that adrenaline would help their cause against last season's fifth-placed side.
However, Bilic quickly discovered that the Baggies have much work to do if they are to ensure that their return to the Premier League is not a brief one with his team perhaps fortunate to only lose by a 3-0 scoreline.
Although it took two Jamie Vardy penalties to put the result beyond doubt, West Brom looked fragile at the back, and it will only encourage Bilic to take a risk on the signing of veteran defender Branislav Ivanovic.
Nevertheless, with a new striker also on his agenda, Bilic finds himself having to make decisions regarding the make-up of his squad, aware that the club have to strike a balance regarding the funds which are made available to him over the coming weeks.
With Everton on the agenda on Saturday afternoon, Bilic will make wholesale changes to his starting lineup on Wednesday, something which will only offer encouragement to their next opponents.
After winning the National League playoff final just a month ago, Harrogate are still riding a crest of a wave as they continue to make the transition into a league club.
The penalty-shootout success at Tranmere Rovers in the previous round came as a bonus, and Simon Weaver would have been ecstatic with how his players disposed of Southend at the weekend.
However, Weaver has a job on his hands to manage both expectations and the upcoming schedule, which also includes an FA Trophy semi-final against Notts County next week.
Although that could lead to a few alterations being made for this contest, West Brom will not relish the task of facing a team who are playing with belief and have little to lose on their big night at The Hawthorns.
West Bromwich Albion form (all competitions): L
Harrogate Town EFL Cup form: D
Harrogate Town form (all competitions): DW
Bilic will almost certainly revert to four at the back for this contest, a move which will see defenders drop out of the first XI.
As for Harrogate, changes feel inevitable with important matches against Walsall and Notts County to come within six days of Wednesday's game.
West Bromwich Albion possible starting lineup:
Button; Furlong, Kipre, Hegazi, O'Shea; Grosicki, Sawyers, Harper, Edwards; Robson-Kanu, Austin
Harrogate Town possible starting lineup:
Minter; Fallowfield, Smith, Lokko, Jones; Thomson, Falkingham, Kirby, Walker; Beck, Stead
We say: West Bromwich Albion 4-2 Harrogate Town
Given their respective ambitions, we expect goals in this match and plenty of them. However, while Harrogate are playing with the confidence which will concern the Baggies at one end, we feel that the home side will have too much firepower for their lower-league opponents at the other.