Florian Kohfeldt's side lost 3-0 at home to Eintracht Frankfurt on Wednesday to remain in 17th position in the table, while Wolfsburg occupy sixth, having gathered 42 points from their 29 matches this season.
Bremen have not operated outside of the Bundesliga since the 1980-81 campaign, but the team are certainly in a battle to secure their top-flight status this season.
Indeed, a record of six wins, seven draws and 16 defeats from 29 matches has left them in 17th position in the table, three points off the safety of 15th spot with nine games left.
Bremen's position is disappointing but far from terminal, and they have shown signs of life since returning to action in the middle of May, amid the coronavirus pandemic.
Indeed, Die Werderaner picked up seven points from their three matches against Freiburg, Borussia Monchengladbach and Schalke 04 between May 23 and May 30.
Kohfeldt's side could not build on their positive run at home to Frankfurt on Wednesday, though, as they suffered a 3-0 defeat to leave themselves firmly in trouble ahead of Sunday's clash.
Wolfsburg actually also lost to Frankfurt in their last match, suffering a 2-1 defeat to the strugglers last weekend, and their form has been mixed since returning to action in the middle of May.
Indeed, Die Wolfe have beaten Augsburg and Bayer Leverkusen in two of their last four matches but have lost to Borussia Dortmund and Frankfurt to keep the race for sixth wide open.
Wolfsburg are currently in charge of the final Europa League position, although they are only ahead of seventh-placed Hoffenheim on goal difference, while Freiburg and Hertha Berlin will also believe that they are both firmly in the argument for sixth position at this stage of the campaign.
There is no question that Oliver Glasner's side will be eyeing all three points this weekend, but they have incredibly not beaten Bremen in the Bundesliga since November 2015, losing six of the last eight top-flight meetings between the two teams.
Bremen Bundesliga form: DLWDWL
Wolfsburg Bundesliga form: DDWLWL
Wolfsburg form (all competitions): DLWLWL
Bremen possible starting lineup:
Pavlenka; Gebre Selassie, Veljkovic, Moisander, Augustinsson; M. Eggestein, Vogt, Klaassen; Bittencourt, Sargent, Rashica
Wolfsburg possible starting lineup:
Casteels; Mbabu, Pongracic, Brooks, Gerhardt; Schlager, Arnold; Brekalo, Mehmedi, Victor; Weghorst
We say: Werder Bremen 1-1 Wolfsburg
As mentioned above, Bremen have dominated the recent meetings between the two sides, and the strugglers have shown some decent form since returning to action last month. Wolfsburg will feel that they have better quality across the pitch, but we are struggling to separate the two teams in this one.