The Chelsea and Sheffield United youngsters made their debuts from the bench as Wales lost 2-0 to France on Friday night, but Coleman has decided to place faith in the pair for the clash with the 2018 World Cup participants.
Dave Edwards and Tom Lawrence feature in midfield, while Chris Gunter captains the team as the defender makes his 85th appearance, equalling Gary Speed's record for the highest number of caps for an outfield player.
Wales: Ward; Gunter, Chester, Davies, Taylor; Ampadu, Edwards, Brooks, Lawrence, Woodburn; Vokes
Panama: Penedo; Murillo, Baloy, Escobar, Ovalle, Cooper, Heraldez, Vargas, Avila, Perez, Torres
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